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Accumulation of Cyclooxygenase Products of Arachidonic Acid Metabolism in Gerbil Brain During Reperfusion After Bilateral Common Carotid Artery Occlusion
Author(s) -
Gaudet Robert J.,
Alam Iftekhar,
Levine Lawrence
Publication year - 1980
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1980.tb03704.x
Subject(s) - gerbil , arachidonic acid , cyclooxygenase , prostacyclin , ischemia , chemistry , medicine , endocrinology , occlusion , alpha (finance) , anesthesia , biochemistry , enzyme , surgery , construct validity , patient satisfaction
: Several of the cyclooxygenase products of arachidonic acid were measured in the cerebral hemispheres of gerbils subjected to transient interruption of the cerebral circulation. The levels of PGD 2 , PGF 2 α, PGE 2 , TXB 2 , 13,14‐H 2 ‐15‐keto‐PGE 2 , and the stable nonenzymic product of prostacyclin, 6‐keto‐PGF 1 α, were not altered at the end of a 5‐min period of ischemia. However, the onset of reperfusion was accompanied by a rapid accumulation of these products. Levels were highest during the initial period of reperfusion, then decreased to approach control levels after 120 min. PGD 2 , PGF 2 α, and PGE 2 were the predominant metabolites detected. This postischemic accumulation of arachidonic acid metabolites could be blocked by prior administration of inhibitors of cyclooxygenase activity.