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EFFECT OF CONCUSSIVE HEAD INJURY ON CENTRAL CATECHOLAMINE LEVELS AND SYNTHESIS RATES IN RAT BRAIN REGIONS 1
Author(s) -
Huger F.,
Patrick G.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11710.x
Subject(s) - pons , dopamine , catecholamine , midbrain , endocrinology , medicine , hypothalamus , cerebellum , norepinephrine , medulla , striatum , tyrosine hydroxylase , chemistry , biology , central nervous system
—Unanesthetized male Sprague‐Dawley rats were subjected to head injury using a unique acceleration‐deceleration model designed to mimic the most prevalent form of clinical head injury. Endogenous tyrosine, dopamine and norepinephrine were determined fluorometrically and catecholamine synthesis rates were determined by a radioisotopic method. These values were determined in four brain regions: cortex‐striatum, midbrain‐hypothalamus, medulla‐pons, and cerebellum, and were performed at 5 min, 15 min, 1 h, and 2h post‐trauma. Dopamine levels were elevated in the medulla pons region at 5 min after trauma and in the midbrain‐hypothalamus at the 15 min and 1 h time periods. This increase in dopamine levels may reflect disruption of dopamine beta hydroxylase activity. Norepinephrine synthesis rate in the cerebellum was elevated at 2 h after trauma. Changes in the other parameters were observed but appeared to be related to stress, and the effect of stress in this model is discussed.