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PURIFICATION AND EFFECT OF THE NEUROTOXIN FROM THE SEA ANEMONE PARASICYONIS ACTINOSTOLOIDES
Author(s) -
Ishikawa Y.,
Onodera K.,
Takeuchi A.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11707.x
Subject(s) - sea anemone , excitatory postsynaptic potential , toxin , neurotoxin , inhibitory postsynaptic potential , crayfish , anemone , neuromuscular transmission , biology , neurotransmission , synapse , sea urchin , chemistry , biophysics , cnidocyte , biochemistry , neuroscience , microbiology and biotechnology , botany , ecology , endocrinology , cnidaria , receptor , coral
— Three toxic components were isolated from the sea anemone, Parasicyonis actinostoloides . Among these components a main component had an effect on the neuromuscular transmission of the crayfish. The component was purified and found to be a basic polypeptide having a molecular weight of about 2000. Amplitudes of excitatory and inhibitory poslsynaptic potentials were increased by the toxin. It was found that the quantum content increased markedly in the excitatory synapse. The action of the toxin remained for a long time after the nerve–muscle preparation was thoroughly washed. These results suggest that the toxin has an effect on the presynaptic nerve.