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UPTAKE OF [ 14 C]NIPECOTIC ACID INTO RAT DORSAL ROOT GANGLIA
Author(s) -
Minchin M. C. W.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11093.x
Subject(s) - nipecotic acid , dorsum , biophysics , chemistry , biochemistry , stereochemistry , biology , anatomy , neurotransmitter , receptor
— [ 14 C]Nipecotic acid was accumulated in isolated desheathed rat dorsal root ganglia by a saturable process with K m = 48.8 μ m and V max = 2.2 nmol/g/min. The concentration of l ‐2.4‐diamino‐butyric acid required to inhibit the uptake of nipecotic acid by 50% was three times the concentration of β‐alanine required to do the same. Light microscopic autoradiography indicated that the sites of uptake of [ 14 C]nipecotic acid were principally confined to satellite glial cells. It is concluded that nipecotic acid is transported by the GABA uptake system in glia but that it has less affinity for this system than GABA.