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REDOX PROPERTIES OF CYTOCHROME OXIDASE AND VASCULAR REACTIVITY OF ASTROCYTOMAS AND NEUROBLASTOMAS IN VIVO
Author(s) -
Sylvia Avis L.,
Somjen George G.,
Bigner Darell D.,
Rosenthal Myron
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11074.x
Subject(s) - cytochrome c oxidase , cytochrome , in vivo , biology , pathology , chemistry , biochemistry , enzyme , medicine , microbiology and biotechnology
— Dual wavelength reflection spectrophotometry was used to determine steady state changes in the reduction‐oxidation ratio of cytochrome c oxidase ( a,a 3 ) and vascular reactivity accompanying progressive growth of cortical and subcutaneous astrocytomas and neuroblastomas in vivo. Blood volume responses indicate that vessels invading the tumors retain regulatory reactivity typical of the body region of implantation and do not acquire those typical of the tissue of origin of the neoplastic cells. In comparison with non neoplastic tissue, early stage tumor growth was associated with highly oxidized ratios of cytochrome a,a 3 . A transition to highly reduced cytochrome a,a 3 occurred during late stage tumor development. Such differences from normal cerebral tissues reflect alterations in micro‐circulation and respiratory chain function accompanying the dynamics of tumor growth, and could provide a basis for selective therapeutic measures.