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SEROTONIN AND DOPAMINE METABOLITES IN BRAIN REGIONS AND CEREBROSPINAL FLUID OF A PRIMATE SPECIES: EFFECTS OF KETAMINE AND FLUPHENAZINE
Author(s) -
Bacopoulos N. G.,
Redmond D. E.,
Roth R. H.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11048.x
Subject(s) - homovanillic acid , fluphenazine , dopamine , serotonin , ketamine , cerebrospinal fluid , primate , neurotransmitter , medicine , endocrinology , pharmacology , chemistry , anesthesia , psychology , neuroscience , central nervous system , haloperidol , receptor
— The concentration of dopamine (DA) and serotonin (5‐HT) metabolites in brain regions was not altered by doses of ketamine (10mg/kg) which induced dissociative anesthesia in a primate species. Cercopithecus aethiops. Fluphenazine (1.0mg/kg) increased homovanillic acid (HVA) content in all brain regions examined. An increase in HVA and 5‐hydroxyindoleacetic acid (5‐HIAA) concentration was observed in cisternal CSF 4 h after ketamine without a concomitant change in the brain concentration of these metabolites.