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DEPENDENCE OF BRAIN TRYPTAMINE FORMATION ON TRYPTOPHAN AVAILABILITY
Author(s) -
Warsh Jerry J.,
Coscina Donald V.,
Godse Damodar D.,
Chan Peter W.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb11046.x
Subject(s) - tryptamine , pargyline , tryptophan , in vivo , chemistry , endocrinology , medicine , serotonin , biochemistry , biology , amino acid , receptor , microbiology and biotechnology
— The dependence of rat brain tryptamine (TA) formation on tryptophan availability was investigated. Rat brain TA was found to accumulate linearly with respect to time over 90min following pargyline (75 mg/kg. i.p.). The in vivo rate of brain TA appearance was estimated to be 0.1 nmol/g/h. After tryptophan loading the accumulation of brain TA and 5‐HT in pargyline‐pretreated rats was linearly related to both brain and plasma tryptophan concentrations. Low doses of tryptophan (5–10 mg/kg. i.p.) produced statistically significant increments in brain TA formation. The findings of this study indicate that the in vivo formation of TA in rat brain is directly dependent upon brain and plasma tryptophan concentrations.