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DECREASED AXONAL FLUX OF RETROGRADELY TRANSPORTED GLYCOPROTEINS IN EARLY EXPERIMENTAL DIABETES
Author(s) -
Jakobsen J.,
Sidenius P.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb05241.x
Subject(s) - axoplasmic transport , ligature , glycoprotein , sciatic nerve , streptozotocin , medicine , diabetes mellitus , endocrinology , chemistry , anatomy , biology , biochemistry
— Anterograde and retrograde flux of axonal transported glycoproteins were examined in streptozotocin diabetic rats with 4 weeks’duration of the metabolic derangement. [ 3 H]Fucose and [ 14 C]NeuNAc were injected into the fifth lumbar root ganglion and the accumulation of TCA‐PTA insoluble activity proximal and distal to a sciatic nerve ligature was measured. Accumulation of glycoproteins during 2 h collection periods was decreased distal to a ligature in diabetic animals whereas no abnormality of proximal accumulation was observed. These findings demonstrate an abnormality of the retrograde transport of glycoproteins in early experimental diabetes.