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ASTROGLIAL UPTAKE IS MODULATED BY EXTRACELLULAR K +
Author(s) -
Cummins C. J.,
Glover R. A.,
Sellinger O. Z.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb05224.x
Subject(s) - extracellular , extracellular fluid , glucose uptake , chemistry , medicine , biophysics , biochemistry , endocrinology , biology , insulin
— Primary cultures of rat brain astrocytes were used to examine the uptake of the glucose analogue, 2‐deoxy‐ d ‐glucose (2‐DOG). 2‐DOG competes with glucose for uptake, indicating that both are transported by the same carrier system. Extracellular K + at 11.9 mM increased the uptake of 2‐DOG at 2‐DOG concentrations greater than 100 μM. Uptake. appears Na + ‐dependent only at high concentrations of 2‐DOG. This suggests that the extracellular concentrations of Na + and K + may regulate the astrocytic uptake of 2‐DOG.