Premium
THE EFFECT OF FASTING ON THE METABOLISM OF 5‐HYDROXYTRYPTAMINE AND DOPAMINE IN THE BRAIN OF THE MOUSE
Author(s) -
Fuenmayor L. D.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb05178.x
Subject(s) - homovanillic acid , probenecid , dopamine , striatum , endocrinology , medicine , dopaminergic , forebrain , chemistry , 3,4 dihydroxyphenylacetic acid , serotonin , biology , central nervous system , receptor
— The turnover of 5‐hydroxytryptamine in the forebrain and of dopamine in the striatum was studied in mice fasted for 20 h. Such mice showed an increased tissue concentration of 5‐hydroxyindoleacetic acid in the forebrain and an increased accumulation of this acid after probenecid. Fasted mice also showed a higher concentration of homovanillic acid in the striatum than fed mice. However, the administration of probenecid produced a smaller increase in homovanillic acid concentration in fasted than in fed mice. The decay of dopamine following α‐methyl‐ p ‐tyrosine was reduced in fasted mice at 2 h, but not at 1 h or 6 h after administration of the inhibitor. The possibility that fasting increases the activity of some dopaminergic neurones while decreasing the activity of others is considered. The existence of a pool of homovanillic acid at a site within the striatum where the probenecid‐sensitive transport is not effective is postulated.