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LOCALIZATION OF GLUTAMINASE IN THE RAT NEOSTRIATUM
Author(s) -
McGeer E. G.,
McGeer P. L.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb04595.x
Subject(s) - glutaminase , kainic acid , glutamate decarboxylase , striatum , gabaergic , glutamate receptor , substantia nigra , medicine , endocrinology , chemistry , biology , enzyme , biochemistry , dopamine , inhibitory postsynaptic potential , receptor , dopaminergic
— Glutaminase activity in rat striatal tissue was not significantly decreased by lesions of the cortico‐striatal tract which depressed striatal glutamate uptake by 47% but was markedly decreased following intrastriatal injections of kainic acid. There also appeared to be a linear correlation between glutaminase and glutamic acid decarboxylase activities in the substantia nigra of rats injected intrastriatally with kainic acid. The results suggest that most of the glutaminase activity in these regions is localized in GABAergic structures and provide no evidence for the occurrence of this enzyme in nerve endings of the glutamergic cortico‐striatal tract.