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Evolution du taux de quelques acides aminés libres cérébraux au cours de l'encéphalopathie hépatique chez le rat porteur dune anastomose porto‐cave Brain amino acids changes during hepatic encephalopathy in the rat with portocaval anastomosis
Author(s) -
Tangapregassom M. J.,
Lantin N.,
Salomon F.,
Bismuth H.,
Grange D.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb02305.x
Subject(s) - amino acid , chemistry , medicine , endocrinology , biochemistry , biology
The free amino acid contents of rat brain have been estimated in animals with portocaval shunt and sham operated up to 1, 2, 3, 5 and 6 weeks after operation. The cyclic amino acid levels (Phe, Tyr and His) were consistently raised from the first to the last weeks. The aliphatic amino acid contents (Ala, Gly, GABA, Lys and Arg) were not found to be significantly different from those of sham operated animals during the first 3 weeks, but they dropped significantly during the 5th and 6th postoperative weeks. Consideration is given to the possibility that the increase of brain cyclic amino acids and delayed fall of aliphatic amino acid contents may explain other results (i.e. drop of sleep and pain thresholds) which have been described in animals with a similar portocaval shunt.