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LOCATING THE MAJOR GLYCOPROTEIN (P o PROTEIN) IN THE X‐RAY PROFILE OF FROG SCIATIC‐NERVE MYELIN
Author(s) -
Blaurock A. E.,
Nelander J. C.
Publication year - 1979
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1979.tb02288.x
Subject(s) - myelin , extracellular , myelin associated glycoprotein , glycoprotein , chemistry , biophysics , myelin sheath , sciatic nerve , myelin basic protein , crystallography , biochemistry , biology , anatomy , central nervous system , neuroscience
Some detailed X‐ray profiles have been put forward for frog sciatic‐nerve myelin in the past 8 y. In this paper we interpret one of these. Much of the myelin protein is located in the extracellular half of the membrane. On the basis of a chemical analysis and other recently published data indicating the sidedness of some myelin proteins, we suggest that the major glycoprotein (P o protein) is inserted into the extracellular half of the myelin bilayer and that it extends into the extracellular space. Our interpretation is consistent with known physical properties of the P o protein. Other myelin proteins have not yet been located. Electron densities and average hydrophobicities of some myelin proteins have been calculated, as well as electron densities and scattering powers of some myelin lipids.