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EFFECT OF CORTISONE AND THYROXINE ON ACID GLYCOSIDASES IN RAT FOREBRAIN AND CEREBELLUM DURING EARLY POSTNATAL DEVELOPMENT
Author(s) -
Lau Herbert C.,
Horowitz Carolyn,
Jumawan Jocelyn,
Koldovsky Otakar
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb12458.x
Subject(s) - forebrain , cortisone , endocrinology , medicine , cerebellum , period (music) , enzyme , cortisone acetate , biology , chemistry , central nervous system , biochemistry , physics , acoustics
— l ‐Thyroxine (200 μg/100 g B.W.) or cortisone‐acetate (5 mg/100 g B.W.), administered for 4 consecutive days, affected several lysosomal enzymes in forebrain and cerebellum of rats during various periods of the first month of postnatal development; their effect was age dependent as well as organ specific. Extending thyroxine or cortisone treatment to 7 days (from day 2 to 9) affected enzyme activity more than the 4‐day treatment period.