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STIMULATION OF MUCLEAR RNA SYNTHESIS IN DENERVATED SKELETAL MUSCLES
Author(s) -
Held Irene R.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb10451.x
Subject(s) - denervation , stimulation , biology , anatomy , endocrinology , skeletal muscle , medicine , rna , endogeny , chemistry , gene , biochemistry
— The endogenous activities of the RNA polymerases A and B are higher in nuclei isolated from slow‐twitch soleus and fast‐twitch extensor digitorum longus muscles which have been denervated for 2–3 days than in nuclei isolated from sham‐operated, contralateral muscles. This stimulation is not observed immediately after denervation and declines by the fifth day. The results suggest that some neural influence is exerted upon the contiguous muscle cell at the level of gene transcription.