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BINDING OF 5‐HYDROXYTRYPTAMINE TO ACIDIC LIPIDS IN AN AQUEOUS MEDIUM
Author(s) -
Johnson David A.,
Merlone Steven C.,
Loh Horace H.,
Ellman George L.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb07845.x
Subject(s) - phosphatidylinositol , phosphatidic acid , chemistry , affinities , tryptamine , biochemistry , stereochemistry , phospholipid , signal transduction , membrane
— The affinities of 5‐hydroxy‐[ 3 H]tryptamine (5‐HT) for cerebroside sulfate, 1‐phosphatidylinositol, 1‐phosphatidylinositol 4‐phosphate, 1‐phosphatidylinositol 4,5‐bisphosphate, phosphatidic acid, and phosphatidyl serine were determined in an aqueous medium. They were observed to be, in general, much lower than and poorly correlated with the values previously reported by J ohnson et al (1977a), measured in isobutanol. This suggested that these lipids probably are not 5‐HT receptors and that drug affinities measured in organic media must be evaluated with caution.