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EFFECT OF BRAIN CORTEX PHOSPHOLIPIDS ON ADENYLATE‐CYCLASE ACTIVITY OF MOUSE BRAIN
Author(s) -
Leon A.,
Benvegnu D.,
Toffano G.,
Orlando P.,
Massari P.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb07030.x
Subject(s) - adenylate kinase , cyclase , phosphatidylserine , stimulation , dopamine , chemistry , medicine , endocrinology , biochemistry , biology , enzyme , phospholipid , membrane
— Intravenous injection of a sonicated dispersion of bovine brain phospholipids results in a significant change in both NaF‐dependent and dopamine dependent adenylate cyclase activity. High dosage of phospholipids inhibits the dopamine dependent, but not the NaF dependent, adenylate cyclase activity. The stimulation of cyclase activity is accompanied by an increased level of cAMP in mice brains. Treatment with haloperidol abolishes the increase in cAMP. Among individual phospholipids, phosphatidylserine is the most active component for inducing the activation of DA‐dependent adenylate cyclase activity.