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CEREBRAL METABOLIC AND VASCULAR EFFECTS OF BARBITURATE THERAPY FOLLOWING COMPLETE GLOBAL ISCHEMIA
Author(s) -
Steen P. A.,
Milde J. H.,
Michenfelder J. D.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb06257.x
Subject(s) - ischemia , medicine , cerebral blood flow , pentobarbital , anesthesia , barbiturate , ligation , cardiology
Complete global cerebral ischemia was induced in dogs by temporary ligation of the ascending aorta for 10min. Prior to the ischemic period, half of the animals were given pentobarbital 30‐38 mg/kg, a maneuver previously reported to prevent or attenuate cerebral damage in this same model. Cerebral blood flow (CBF) and cerebral metabolic rate (CMR O2 ) were followed from prior to the ischemic period to 6 h post‐ischemia. At varying time intervals following ischemia, brain biopsies were obtained and analyzed for cerebral metabolites to determine the cerebral energy state. Only a few differences were observed between pentobarbital‐treated and untreated animals. Post‐ischemic CMR O2 , stabilized at a significantly lower level in treated than in untreated animals. However, CBF was proportionately lower and thus O 2 delivery relative to O 2 needs in the two groups was comparable. Also in both groups, the CBF and CMR O2 stabilized at levels significantly below pre‐ischemia controls. Cerebral energy stores in both groups were depleted after 10min of ischemia but were restored to near normal within 4min post‐ischemia. Total restoration of the adenine nucleotide pool and ATP were delayed as was the return of brain lactate to normal. A 10min period of post‐ischemic hyperemia was observed in all animals and in the initial 4min post‐ischemia CMR O2 was also increased. The latter is probably accounted for by the O 2 needs for restoration of cerebral energy and O 2 stores. We conclude that cerebral protection as provided by barbiturates following complete global ischemia cannot be accounted for by any measurable effect on CBF, CMR O2 , or the cerebral energy stores during the initial 6 h post‐ischemia.