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THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM
Author(s) -
Markstein R.,
Herrling P. L.,
Asper H. R. Buurki. H.,
Ruch W.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb06240.x
Subject(s) - bromocriptine , apomorphine , endocrinology , striatum , medicine , adenylate kinase , chemistry , monoamine neurotransmitter , cyclase , dopamine , dopaminergic , serotonin , prolactin , receptor , stimulation , hormone
In slices and homogenate from rat brain striatum bromocriptine in marked contrast to DA. NA and apomorphine. had no stimulatory effect on adenylate cyclase activity, but antagonised the stimulatory effects of both NA and DA. Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and limbic structures 3h after drug administration. However, an increase in the turnover of NA in the brain stem and that of 5‐HT in the cortex was observed 4h following treatment with bromocriptine. Possible modes of action of bromocriptine are discussed.