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THE UTILIZATION OF GLUTAMINE BY THE RETINA: AN AUTORADIOGRAPHIC AND METABOLIC STUDY
Author(s) -
Voaden M. J.,
Lake N.,
Marshall J.,
Morjaria B.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb00149.x
Subject(s) - glutamine , retina , glutamate receptor , amino acid , glutamic acid , biology , guinea pig , inner nuclear layer , biochemistry , inner plexiform layer , metabolism , aspartic acid , outer nuclear layer , microbiology and biotechnology , anatomy , neuroscience , endocrinology , receptor
The cells able to accumulate exogenously applied [ 3 H]glutamine in rat, cat, frog, pigeon and guinea pig retinas have been located by autoradiography, and the fate of the labelled glutamine, as regards its incorporation into aspartic, glutamic and γ‐amino‐butyric acids, followed for 60min. The results support the notion of glutamine as a precursor of transmitter amino acids in some neurones. In particular, it would appear to be a source of a relatively stable pool of GABA which may be located, with species variation, in amacrine or ganglion cells. In the pigeon retina a glutamate pool incorporates and retains a major percentage of the label, and perikarya in the middle of the inner nuclear layer of the tissue are predominantly labelled.