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EFFECT OF ELECTROSHOCK ON THYMIDINE INCORPORATION INTO RAT BRAIN DNA
Author(s) -
Giuditta A.,
Abrescia P.,
Rutigliano B.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb00137.x
Subject(s) - thymidine , dna , dna synthesis , inhibitory postsynaptic potential , endocrinology , medicine , chemistry , electroconvulsive therapy , pharmacology , biology , electroconvulsive shock , biochemistry
Administration of electroconvulsive shocks in rats induces a marked inhibition of the process of thymidine incorporation into cortical DNA. The inhibitory effect reaches its maximum after 10–15 min. Percentage incorporation returns to normal values within one hour of the treatment. These findings may suggest the participation of a metabolically active fraction of DNA in neural functions.