Premium
ON THE STRUCTURE OF A NEW, FUCOSE CONTAINING GANGLIOSIDE FROM PIG CEREBELLUM
Author(s) -
Sonnino S.,
Ghidoni R.,
Gall G.,
Tettamanti G.
Publication year - 1978
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1978.tb00132.x
Subject(s) - fucose , ganglioside , biochemistry , galactose , ceramide , glycosphingolipid , chemistry , stereochemistry , cerebellum , biology , endocrinology , apoptosis
A new ganglioside, provisionally named GLIVa, was isolated in pure form from pig cerebellum. Ganglioside GLIVa is a disialoganglioside containing fucose. Its basic neutral glycosphingolipid core is the gangliotetraose ceramide: Gal, β 1 → 3 GalNAc, β 1 → 4 Gal, β 1 → 4 Glc, β 1 → Cer. Fucose is α‐glycosidically linked to the 2‐position of external galactose and one N ‐acetylneuraminic acid is linked to the other one by an α, 2 → 8 linkage. Thus the total structure of ganglioside GLIVa is the following: Fuc, α 1 → 2 Gal, β 1 → 3 GalNAc, β 1 → 4 (NeuAc, α 2 48 NeuAc, α 2 → 3) Gal, β 1 → 4 Glc, β 1 → Ceramide. According to the IUPAC‐IUB Commission on Biochemical Nomenclature is indicated as II 3 α(NeuAc) 2 IV 2 αFuc‐GgOse 4 Cer.