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METABOLISM OF GLUTAMIC ACID AND RELATED AMINO ACIDS IN THE BRAIN STUDIED WITH 14 C‐LABELLED GLUCOSE, BUTYRIC ACID AND GLUTAMIC ACID IN HYPERCAPNIC RATS
Author(s) -
Weyne J.,
Leuven F.,
Demeester G.,
Leusen I.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb10695.x
Subject(s) - glutamine , glutamic acid , hypercapnia , butyric acid , metabolism , chemistry , aspartic acid , biochemistry , amino acid , medicine , respiratory system
— The influence of hypercapnia on the metabolism of glutamic acid, aspartic acid, glutamine and GABA in rat brain was studied using three different precursors. Acute hypercapnia induced a fall in the concentration of glutamic and aspartic acid, and a rise in the concentration of glutamine and GABA. Acute hypercapnia had a profound effect on the relative specific radioactivity of glutamine indicating that the excess glutamine, present in the brain in hypercapnia, was synthetized from glutamic acid in the compartment where it could become quickly labelled from butyric and glutamic acid, but not from glucose. This effect was maintained in chronic hypercapnia.