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THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l ‐DOPA OR d ‐AMPHETAMINE 1
Author(s) -
Moskowitz M. A.,
Rubin Deborah,
Liebschutz J.,
Munro H. N.,
Nowak T. S.,
Wurtman R. J.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb10627.x
Subject(s) - polysome , hyperthermia , amphetamine , chemistry , permissive , pharmacology , biophysics , biochemistry , biology , endocrinology , dopamine , medicine , rna , ribosome , genetics , gene
— l ‐DOPA or d ‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.