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EFFECT OF DIETARY PROTEIN ON URINARY 5‐HYDROXYINDOLEACETIC ACID LEVELS 1
Author(s) -
Nomura M.,
Colmenares J. L.,
Wurtman R. J.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb09618.x
Subject(s) - 5 hydroxyindoleacetic acid , serotonin , casein , aromatic l amino acid decarboxylase , endocrinology , medicine , urinary system , carbidopa , dietary protein , amino acid , low protein diet , chemistry , peripheral , biology , biochemistry , dopamine , levodopa , receptor , disease , parkinson's disease
— Among rats consuming diets containing 0%, 18%, or 40% protein (in the form of casein) for 4 consecutive days, urinary 5‐hydroxyindoleacetic acid (5‐HIAA) levels varied markedly as a function of the protein content, whether 5‐HIAA was expressed as μg/rat/day or as μg/kg body weight/day. These differences could not be attributed to 5‐hydroxyindoles in the diet; they probably reflected diet‐dependent changes in serotonin synthesis. If animals were treated concurrently with carbidopa (a drug that blocks aromatic L‐amino acid decarboxylase activity in the gut and other peripheral tissues but not in the CNS), urinary 5‐HIAA levels fell, and the effect of dietary protein on the 5‐HIAA largely disappeared. These observations indicate that serotonin synthesis in peripheral organs, as in brain, is under acute nutritional control.