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OCCURRENCE OF ALKANES IN BRAIN MYELIN. COMPARISON BETWEEN NORMAL AND QUAKING MOUSE
Author(s) -
BOURRE J. M.,
CASSAGNE C.,
LARROUQUEREREGNIER S.,
DARRIET D.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb07781.x
Subject(s) - myelin , chemistry , microsome , chromatography , biochemistry , biology , central nervous system , neuroscience , enzyme
— Alkanes, a new class of neurolipid, were found in mouse brain, the level being reduced in the Quaking mutant. These hydrocarbons are concentrated in myelin; minor amounts being found in microsomes, mitochondria and synaptosomes. The average recovery is 7.1 μg/mg in normal myelin, 2.2 in the Quaking myelin. The distribution pattern of these alkanes was determined by gas liquid chromatography and was found to differ in normal and Quaking myelin; the hydrocarbons consist mainly of n ‐alkanes ranging from C 21 to C 32 with even and odd aliphatic chains.