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STUDIES ON FORMATION OF γ‐GLUTAMYLAMINES IN RAT BRAIN AND THEIR SYNTHETIC AND CATABOLIC ENZYMES
Author(s) -
TSUJI M.,
MATSUOKA Y.,
NAKAJIMA T.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb07779.x
Subject(s) - tyramine , catabolism , dopamine , serotonin , enzyme , kidney , chemistry , biochemistry , medicine , endocrinology , biology , receptor
Abstract— γ‐Glutamylation of p ‐tyramine, noradrenaline, dopamine and serotonin in rat brains was demonstrated by intraventricular injections of the radioactive amines and isolation of the γ‐glutamylamines from the acidic extract of the rat brains. Formation of these γ‐glutamylamines was proved to be catalysed by γ‐glutamyltranspeptidase prepared from both rat kidney and brain. However, these compounds were degraded by γ‐glutamylcyclotransferase of rat brain, but not by the emzyme of rat kidney.