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STUDIES ON THE TISSUE AND SUBCELLULAR DISTRIBUTION OF β‐ N ‐OXALYL‐ l ‐α, β‐DIAMINOPROPIONIC ACID, THE LATHYRUS SATIVUS NEUROTOXIN
Author(s) -
Lakshmanan J.,
Padmanaban G.
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb06517.x
Subject(s) - lathyrus , neurotoxin , in vivo , lathyrism , synaptosome , glutamate receptor , spinal cord , biology , population , biochemistry , biophysics , in vitro , neuroscience , botany , medicine , receptor , microbiology and biotechnology , environmental health
— β‐ N ‐Oxalyl‐ l ‐α, β‐diaminopropionic acid (ODAP), the Lathyrus sativus neurotoxin can be detected in significant concentrations in the synaptosomal fractions isolated from young rat brain and adult monkey spinal cord, when these animals manifest neurological symptoms after ODAP administration. However, isolated synaptosomes fail to exhibit any transport system for ODAP uptake. ODAP administered in vivo appears to get localized in a population of synaptosomes which exhibit a high affinity uptake system for glutamate.