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RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Author(s) -
Sokoloff Louis
Publication year - 1977
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1977.tb03919.x
Subject(s) - relation (database) , energy metabolism , function (biology) , citation , medicine , library science , computer science , biology , database , evolutionary biology
THE H R A I N is a complex organ composed of many structural and functional components with markedly different and independently regulated levels of functional and metabolic activity. In more homogeneous organs that do readily recognizable physical and chemical work. such as the heart, skeletal muscle. and kidney, a close relationship between functional activity and energy metabolism is well established. The existence of a similar relationship in the tissues of the CNS has been more difficult to prove, partly because of uncertainty about the nature of the work associated with nervous functional activity, but mainly because of the difficulty in assessing the lcvels of functional and metabolic activities in the Same functional component of the brain at the same time. Pathological and pharmacological conditions with gross and diffuse effects on cerebral functional activity, particularly those that alter the level of consciousness, have been shown to be associated with changes in overall cerebral metabolic rate (KEIY, 1950, 1957; LASSES, 1959; SOKOLOFF. 1976), but such associations could reflect separate independent consequences of cellular dysfunction rather than a direct relationship between cerebral functional activity and energy metabolism. Changes in the metabolic rate of the brain as a whole have generally not been found during physiological alterations of cerebral functional activity (LASSEN, 1959; SOKOLOFF, 1969, 1976). What has clearly been needed is a method that measures the rates of energy metabolism in specific discrete regions of the brain in normal and altered states of functional activity. The recently developed [14C]deoxyglucose technique (SOKOLOFF et al., 1977) appears to fulfill this need. It can be used to measure quantitatively the local rates of glucose utilization simultaneously in all the macroscopically visible structures of the brain. It can be applied to normal conscious animals as well as those under experimentally altered states of cerebral activity. Furthermore.