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A MODULATING ROLE OF PITUITARY‐ADRENAL AXIS IN CEREBRAL METABOLISM OF ADENOSINE 3′,5′‐MONOPHOSPHATE
Author(s) -
Nakagawa K.,
Kuriyama K.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb12290.x
Subject(s) - medicine , endocrinology , adenylate kinase , cyclase , adrenalectomy , hypophysectomy , dexamethasone , adenosine , phosphodiesterase , adenosine monophosphate , in vivo , chemistry , cerebral cortex , cyclic adenosine monophosphate , adrenal cortex , aldosterone , metabolism , biology , hormone , enzyme , biochemistry , receptor , stimulation , microbiology and biotechnology
— The effect of adrenalectomy or hypophysectomy on the metabolism of adenosine 3′,5′‐monophosphate (cyclic AMP) in the cerebral cortex of male Wistar rats was investigated. The bilateral removal of adrenal glands reduced significantly the activity of cerebral adenylate cyclase [EC 4.6.1.1]. whereas that of cyclic 3′.5′‐nucleotide phosphodiesterase [EC 3.1.4.17] remained unchanged. The formation of cyclic AMP measured in cerebral cortical slices from adrenalectomized or hypophysectomized rats was also diminished. Decreases in the activity of adenylate cyclase and formation of cyclic AMP following adrenalectomy were antagonized by in vivo administration of dexamethasone or aldosterone, while those observed in hypophysectomized rats were restored by ACTH or dexamethasone. It is suggested that the pituitary adrenal axis has a modulating role in the metabolism of cerebral cyclic AMP, possibly by changing adenylate cyclase activity.