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ON THE STRUCTURE OF TWO NEW GANGLIOSIDES FROM BEEF BRAIN
Author(s) -
Ghidoni R.,
Sonnino S.,
Tettamanti G.,
Wiegandt H.,
Zambotti V.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb12275.x
Subject(s) - ganglioside , fucose , ceramide , glycosphingolipid , galactose , stereochemistry , biochemistry , chemistry , apoptosis
— Two new gangliosides were isolated in pure form from beef brain. They were provisionally named ganglioside G5a and G5b. Ganglioside GSa is a monosialoganglioside containing fucose. Its basic neutral glycosphingolipid core is the gangliotetraose ceramide: Gal (1 —> 3) GalNac (1—> 4) Gal (1 —> 4) Glc (1—>) ceramide, most likely with β‐linkages. Fucose is linked to the 2‐position of external galactose, N ‐acetylneuraminic acid to the 3‐ position of internal galactose. Ganglioside G5b is a mixture of at least two isomeric disialogangliosides containing N ‐acetylneuraminic acid and N ‐glycolylneura‐minic acid. The major isomer has the following structure: NeuNac (α,2—>3) Gal (β,1—>3) GalNac (β, 1 —> 4) (NeuNglα, 2 —> 3) gal (β,1—>4) Glc (β,1 —>)‐ceramide. The minor isomer contains N ‐acetylneur‐aminic acid and N ‐glycolylneuraminic acid in an inverted linkage position.