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CHANGES IN THE GABA SYSTEM IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS‐INDUCED PARALYSIS
Author(s) -
Gottesfeld Zehava,
Teitelbaum Dvora,
Webb Cynthia,
Ar Ruth
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb10396.x
Subject(s) - glutamate decarboxylase , spinal cord , encephalomyelitis , lumbar spinal cord , paralysis , cerebellum , choline acetyltransferase , glutamate receptor , chemistry , anesthesia , endocrinology , medicine , central nervous system , neuroscience , biology , biochemistry , enzyme , surgery , receptor
— The content of γ‐aminobutyric acid (GABA), but not glutamate, and the uptake of [ 3 H]GABA by synaptosomes was reduced in the lumbar cord of guinea pigs during experimental allergic encephalomyelitis (EAE)‐induced hind limb paralysis. The decrease in glutamate decarboxylase (GAD) activity in the dorsal and ventral parts of the cord was confined to the lumbar region, and appeared before the onset of motor dysfunction. No change in activity was found in the thoracic cord, motor cortex, cerebellum or striatum. GAD activity remained unchanged in animals which were EAE‐sensitized but did not develop the clinical symptoms. Choline acetyltransferase activity did not change in the cord during paralysis.