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A STUDY OF GLYCOLYTIC AND PENTOSE PHOSPHATE SHUNT ENZYMES IN RELATIONSHIP TO THE ALTERED PERMEABILITY IN THE BLOOD‐BRAIN BARRIER
Author(s) -
Bennett M. J.,
Ogilvy. K. M.,
Blake G. M.,
Lewtas N.,
Timperley W. R.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb06997.x
Subject(s) - hexokinase , pentose phosphate pathway , glycolysis , enzyme , biochemistry , hexose , dehydrogenase , chemistry , catabolism , biology
The activities of a number of glycolytic and hexose‐monophosphate shunt cnzymes in 14 cases of intracranial pathology have been compared with specific uptake of the radioactive tracer 99m Tc‐pertechnetate. Strong positive correlations were observed betwcen isotope uptake and the activities of hexokinase and glucose‐6‐phosphate dehydrogenase. No close correlation was observed with other enzymes studied. Hexokinase is considered to be one of the major rate determining enzymes for the glycolytic catabolism of carbohydratcs and the subsequent production of nucleotidc triphophosphates which are vital in active transport mechanisms. This could indicate an important role for this enzyme in blood‐brain barrier kinetics.