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HOMOVANILLIC ACID AND 3‐METHOXY‐4‐ HYDROXYPHENYLETHYLENEGLYCOL PRODUCTION BY THE MONKEY SPINAL CORD
Author(s) -
Kesslex J. A.,
Gordon E. K.,
Reid J. L.,
Kopin I. J.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb06986.x
Subject(s) - homovanillic acid , spinal cord , cisterna magna , probenecid , cerebrospinal fluid , lumbar , lumbar spinal cord , endocrinology , anesthesia , medicine , perfusion , central nervous system , chemistry , anatomy , serotonin , receptor , psychiatry
The release of homovanillic acid (HVA) and 3‐methoxy‐4‐hydroxyphenylethyleneglycol (MHPG) into CSF by the monkey spinal cord was investigated with spinal subarachnoid perfusion of 20 rhesus monkeys. The preperfusion concentration of HVA in lumbar CSF was 365 ng/ml and in cisternal CSF was 365 ng/ml, while the concentrations of MHPG were 28.3 and 40.4 ng/ml respectively. HVA originating from the spinal cord appeared in the perfusate at a rate of 2.4 and MHPG at 1.4 ng/min. Treatment with probenecid either intraperitoneally or intrathecally did not alter the rate of release into CSF of these metabolites by the spinal cord but did significantly increase the rate of appearance in the cisterna magna of HVA originating from the brain. MHPG and HVA in lumbar CSF are therefore derived in part from spinal cord metabolism.