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EFFECTS OF DOPAMINERGIC AGONISTS AND ELECTRICAL STIMULATION OF THE MIDBRAIN RAPHÉ ON THE RELEASE OF 5‐HYDROXYTRYPTAMINE FROM THE CAT BRAIN IN VIVO
Author(s) -
Chiueh C. C.,
Moore K. E.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb04483.x
Subject(s) - midbrain , endocrinology , medicine , apomorphine , stimulation , chemistry , cerebrospinal fluid , dopaminergic , efflux , serotonin , caudate nucleus , dopamine , hypothalamus , cats , central nervous system , biology , biochemistry , receptor
—The cerebroventricular system of spinal‐sectioned cats was perfused with artificial cerebrospinal fluid after the intraventricular administration of [ 3 H]tryptophan, and the perfusate was analyzed for [ 3 H]5‐HT. At the end of the experiment the relative contents of [ 3 H]5‐HT in regions lining the cerebroventricular system (caudate nucleus, septum, hypothalamus) were essentially the same as the endogenous 5‐HT contents. Electrical stimulation of the midbrain raphé did not alter the efflux of total radioactivity but significantly increased the efflux of [ 3 H]5‐HT. The addition of potassium to the perfusing CSF also increased the efflux of [ 3 H]5‐HT, while additions of d ‐amphetamine, apomorphine or l ‐DOPA were without effect.