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METABOLISM OF GLUTAMATE AND RELATED AMINO ACIDS IN THE 10‐DAY‐OLD MOUSE BRAIN: EXPERIMENTS WITH LABELLED ACETATE AND β‐HYDROXYBUTYRATE
Author(s) -
Berg C. J.,
Ronda G.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb02628.x
Subject(s) - glutamate receptor , amino acid , labelling , metabolism , biochemistry , glutamic acid , chemistry , biology , receptor
– The pattern of incorporation of [ 3 H, 1‐ 14 C]‐ and [ 3 H. 2‐ 14 C]acetate into glutamate and related amino acids was studied in the brain of 10‐day‐old mice. A comparison of these patterns with those obtained for the adult brain led to the suggestion that the glutamate pool labelled directly by acetate is a much larger fraction of the total glutamate pool in the 10‐day‐old brain than it is in the adult brain. Some data on the pattern of labelling of brain amino acids by 3‐hydroxybutyrate. glucose and acetate support the hypothesis that direct carboxylation of pyruvate is somewhat more active in the immature than in the mature brain. Differences in the labelling patterns of free and protein‐bound brain amino acids by acetate, do indicate that the free amino acid pool labelled by acetate is not the precursor pool for protein synthesis.