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THE MOTOR END‐PLATE SPECIFIC FORM OF ACETYLCHOLINESTERASE: APPEARANCE DURING EMBRYOGENESIS AND RE‐INNERVATION OF RAT MUSCLE
Author(s) -
Vigny M.,
Koenig Jeanine,
Rieger F.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb02614.x
Subject(s) - acetylcholinesterase , denervation , anatomy , neuromuscular junction , aché , biology , hindlimb , embryo , skeletal muscle , motor nerve , motor unit , neuroscience , microbiology and biotechnology , enzyme , biochemistry
– We have solubilized three active molecular forms of AChE from rat muscle and have confirmed the presence of one of these forms (EP form, apparent sedimentation coefficient: 16 s) uniquely at the motor end‐plate regions of several skeletal muscles. This form was never detected in smooth muscle extracts. In sternocleidomastoïdian muscle it disappeared after denervation and reappeared after re‐innervation in the region where nerve and muscle had come in contact. During the embryonic development of hind leg muscles the EP form appeared on the 14th or 15th day of gestation. The EP form of muscle AchE appears to be an excellent biochemical marker of the neuromuscular junction.