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ALTERATIONS IN BRAIN OCTOPAMINE AND BRAIN TYROSINE FOLLOWING PORTACAVAL ANASTOMOSIS IN RATS
Author(s) -
James J. H.,
Hodgman Jane M.,
Funovics J. M.,
Fischer J. E.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb01568.x
Subject(s) - tyrosine , octopamine (neurotransmitter) , endocrinology , medicine , portacaval anastomosis , hepatic encephalopathy , portacaval shunt , encephalopathy , anastomosis , biology , chemistry , biochemistry , portal hypertension , receptor , cirrhosis , surgery , serotonin
— Following portacaval anastomosis in the rat, plasma and brain tyrosine are markedly elevated, although brain tyrosine is increased to a significantly greater degree than plasma tyrosine. Both plasma and brain tyrosine as well as brain octopamine correlated well with a presumed index of impaired hepatic function, the ratio of liver weight to body weight in shunted rats. A significant positive correlation was observed between brain octopamine and brain tyrosine. The significance of these findings to the etiology and treatment of clinical hepatic encephalopathy is discussed.