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EFFECT OF DIETARY PROTEIN AND CALORIE DEFICIENCY ON TRYPTOPHAN LEVELS IN THE DEVELOPING RAT BRAIN
Author(s) -
Kalyanasundaram S.
Publication year - 1976
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1976.tb00335.x
Subject(s) - tryptophan , calorie , endocrinology , medicine , protein diet , biology , dietary protein , low protein diet , brain development , food protein , physiology , body weight , biochemistry , amino acid , neuroscience
— The pattern of development of brain tryptophan in the rat was studied in the progeny of mothers fed a 7.5%; protein diet ad lib. , a 20% protein diet ad lib. and those fed a 20%; protein diet pair‐fed with mothers who received the 7.5% protein. The pattern of development was similar in all three groups. Starting with a high brain tryptophan content at birth, all animals showed a progressive reduction during the next 3 weeks. However, tryptophan levels at birth were several fold higher in the brains of pups born to mothers receiving either the low protein diet fed ad lib. or those born to mothers who received the 20% protein diet in restricted amounts. From the 14th day after birth, tryptophan concentration of brain in undernourished pups was significantly lower until the 35th day. The implications of this finding are discussed.