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THE EFFECT OF HYPERBARIC OXYGENATION ON THE LEVELS OF 5‐HYDROXYTRYPTAMINE, NORADRENALINE, DOPAMINE AND FREE AMINO ACIDS IN WHOLE MOUSE BRAIN
Author(s) -
Huggins A. K.,
Nelson D. R.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb12237.x
Subject(s) - convulsant , taurine , dopamine , valine , chemistry , medicine , serotonin , amino acid , monoamine neurotransmitter , endocrinology , glycine , tryptophan , methionine , oxygen , neurotransmitter , alanine , biochemistry , biology , central nervous system , receptor , organic chemistry
— The effect of hyperbaric oxygenation on the levels of monoamines and free amino acids in whole mouse brain were found to vary with time of exposure and the pressure system used. Depression of 5‐hydroxytryptamine (5‐HT), noradrenaline (NA) and dopamine (DA) levels occurred after 40‐60 min in 100% oxygen at atmospheric pressure. These effects occurred more rapidly at higher pressures but had disappeared by about 20 min. No significant change in free glutamic acid, glycine, tryptophan, tyrosine or taurine levels was observed following exposure for up to 60 min in oxygen at 4 atm. A progressive decrease in alanine occurred when oxygen replaced air and the pressure and exposure time increased. Other changes, detected in post‐convulsant mice only, were increases in the leucine and valine pools. The relationship of these results to other work is discussed.