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AMINO ACID TRANSPORT INTO THE CEREBROSPINAL FLUID OF THE RAT 1
Author(s) -
Franklin G. M.,
Dudzinski D. S.,
Cutler R. W. P.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb11889.x
Subject(s) - glycine , cerebrospinal fluid , amino acid , spinal cord , subarachnoid space , chemistry , perfusion , glycine receptor , extracellular fluid , efflux , biochemistry , medicine , biology , extracellular , neuroscience
— The concentrations of glycine and 6 other amino acids have been assayed in the CSF and plasma of the rat, and regional heterogeneity of CSF amino acid concentration has been found. Steady state flux rates into the cranial and spinal fluid compartments were determined during perfusion with amino acid free medium. The transfer of glycine from blood into both the cranial and spinal subarachnoid fluids was saturable with only several‐fold elevations of plasma glycine. The results are discussed with regard to the putative neurotransmitter function of glycine in the spinal cord.