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CHEMICAL SPECIFICITY OF DOPAMINE TRANSPORT IN THE NIGRO‐NEOSTRIATAL PROJECTION
Author(s) -
McGeer E. G.,
Searl K.,
Fibiger H. C.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb11877.x
Subject(s) - dopamine , substantia nigra , striatum , chemistry , octopamine (neurotransmitter) , amphetamine , endocrinology , medicine , serotonin , dopaminergic , neuroscience , biochemistry , biology , receptor
— Axoplasmic transport of dopamine in the nigro‐neostriatal system has previously been shown by the specific accumulation of labelled dopamine in the striatum following injections of labelled DOPA or dopamine into the substantia nigra. To test the specificity, 17 different labelled materials (pipecolic acid, inulin, taurine, GABA, glycine, histidine, histamine, serotonin, 5‐HTP, D‐amphetamine, 3‐methoxytyramine, dopamine, tyramine, norepinephrine, octopamine and high and low specificity activity DOPA) were injected into the substantia nigra and the distribution of radioactivity in the brain studied after 6 and 24 h. Only the catecholamines and octopamine gave evidence of specific accumulation in the ipsilateral striatum although some of the other compounds caused diffuse labelling of the striatum along with other brain areas.