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REGIONAL DIFFERENCES IN HIGH AFFINITY CHOLINE TRANSPORT VELOCITY IN GUINEA‐PIG BRAIN
Author(s) -
Carroll P. T.,
Buterbaugh G. G.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb11869.x
Subject(s) - choline , guinea pig , brainstem , cholinergic , acetylcholine , cerebral cortex , cerebellum , free nerve ending , biophysics , chemistry , cortex (anatomy) , endocrinology , biology , medicine , neuroscience
— The kinetic parameters of choline accumulation by synaptosomes prepared from different regions of guinea‐pig brain (cortex, brainstem, and cerebellum) were determined. Choline was accumulated by a high affinity transport process for all regions tested and the apparent Michaelis constants were similar. However, the apparent maximal velocities of choline accumulation for the brain regions differed; the differences were related to the amount of acetylcholine formed by the respective regions. The results suggested that the maximal velocity of the high affinity transport process may reflect the density of cholinergic nerve endings within brain regions.