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THE EFFECTS OF HYPERKETONEMIA ON GLYCOLYTIC INTERMEDIATES IN THE DEVELOPING RAT BRAIN
Author(s) -
Ozand P. T.,
Stevenson J. H.,
Tildon J. T.,
Cornrlath M.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb07694.x
Subject(s) - medicine , endocrinology , glycolysis , biology , chemistry , metabolism
— Newborn rats from dams fed on a high fat diet developed increased ketonemia and significant hypertriglyceridemia i.e. “hyperketonemic pups”. This perinatal metabolic stress led to an alteration in the developmental pattern of glycolytic intermediates in their brains. In control rats, the concentration of glucose 6‐phosphate (G6P) in the brain was high at birth, and gradually decreased to adult values by the third week of life. In contrast, the fructose‐1,6‐diphosphate (FDP) concentration was low at birth and increased thereafter. The lactate concentration was also high at birth but decreased to the adult level by the first day of life. In the brains of control pups, lactate and pyruvate concentrations remained relatively constant during the first 3 weeks of life. In the brains of hyperketonemic pups, the concentration of G6P was the same as in the control animals at birth but decreased significantly during the first days of life. During early development the concentrations of FDP and pyruvate were significantly lower and the concentration of lactate, higher in the hyperketonemic pups as compared to the control group. The alteration in the concentration of these glycolytic intermediates in the brains of hyperketonemic pups indicated a change in the developmental pattern of glycolysis. The ratio of [lactate]/[pyruvate] also suggested an increased cytoplasmic redox potential in the brains of hyperketonemic pups during the first week of life.