MORPHINE INDUCED CALCIUM DEPLETION IN DISCRETE REGIONS OF RAT BRAIN  1 | Zendy

Cardenas H. Lee | Zendy; Ross D. H. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

MORPHINE INDUCED CALCIUM DEPLETION IN DISCRETE REGIONS OF RAT BRAIN 1

Author(s) -

Cardenas H. Lee,

Ross D. H.

Publication year - 1975

Publication title -

journal of neurochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.75

H-Index - 229

eISSN - 1471-4159

pISSN - 0022-3042

DOI - 10.1111/j.1471-4159.1975.tb07666.x

Subject(s) - reserpine , (+) naloxone , morphine , calcium , opiate , in vivo , chemistry , medicine , endocrinology , pharmacology , antagonist , biology , receptor , microbiology and biotechnology

— The in vivo administration of a single dose of morphine produces a decrease of tissue calcium in the rat brain. This decrease is observed to be linear, dose‐dependent, time‐dependent and to occur to an equal degree in 8 discrete brain regions. This effect of morphine is blocked by naloxone and exhibits a high degree of sterospecificity. The reserpine induced decrease of brain calcium was not antagonized by naloxone. Differentiation of this response using reserpine and naloxone indicates the possibility of calcium pools in the central nervous system. The results are discussed in terms of a specific effect of opiate drugs and the role of calcium in opiatereceptor interactions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research