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OBSERVATION ON THE PROPERTIES OF DOPAMINE‐β‐HYDROXYLASE 1
Author(s) -
Brown F. C.,
Harralson J. D.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb07663.x
Subject(s) - catalase , autoxidation , chemistry , dopamine , enzyme , ionic strength , sodium , hydrogen peroxide , salt (chemistry) , biochemistry , copper , nuclear chemistry , endocrinology , organic chemistry , biology , aqueous solution
— The activity of dopamine‐β‐hydroxylase is inhibited by copper. It is stimulated by a variety of substances, such as fumarate and sodium chloride, which exert salt‐like effects. Both phenomena are mediated indirectly through an interaction of ascorbate with catalase. The latter is converted to the inactive catalase II, by the autoxidation of ascorbate and other electron donors. Copper accelerates the autoxidation, thereby enhancing the inactivation of catalase. The activity of DβH, which requires catalase, is therefore inhibited. At high ionic strength, i. e. in the presence of high levels of salt, the conversion of catalase to catalase II is prevented, and the DβH reaction proceeds.