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SUPEROXIDE DISMUTASE OF MAMMALIAN NERVOUS SYSTEM
Author(s) -
Fried R.,
Mandel P.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb07658.x
Subject(s) - superoxide dismutase , central nervous system , dismutase , chemistry , nervous system , endocrinology , biochemistry , enzyme , antioxidant , superoxide , oxygen , medicine , radical , nervous tissue , biology , neuroscience , organic chemistry
— Superoxide dismutase was assayed in portions of the nervous system (a) by inhibition of tetrazolium reduction by oxygen radicals, generated enzymically, and (b) by inhibition of tetrazolium reduction by oxygen radicals generated by oxidation of NADH in presence of phenazine methosulphate. Superoxide dismutase activity was found in beef brain, retina and adrenal medulla, as well as in brain, retina and lungs of adult and of newborn rats. Preliminary experiments with rats exposed to hyperbaric oxygen showed no alteration of enzyme activities in tissues of newborn and adult animals. The possible role of superoxide dismutase in the nervous system is discussed.