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THE EFFECTS OF AGE AND ALCOHOL ON (Na + + K + )‐ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN
Author(s) -
Sun A. Y.,
Samorajski T.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb07643.x
Subject(s) - synaptosome , atpase , membrane , age groups , ethanol , alcohol , chemistry , human brain , endocrinology , medicine , biology , biochemistry , enzyme , neuroscience , demography , sociology
— Whole homogenates of mouse brain and nerve‐ending fractions of mouse and human brain were obtained at various age levels representative of maturity and old age. The mice were 3, 8 and 26–29 months old and the humans ranged in age from 19 to 84 y. Measurements of (Na + + K + )‐ATPase in whole brain homogenate of mouse did not reveal any significant differences in relation to age. However, the ability of ethanol at various concentrations to inhibit membrane‐bound synaptosomal (Na + + K + )‐ATPase was significantly greater in older mice and humans. The data are interpreted as indicating a change in the property of synaptic membranes as a consequence of advancing age.