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BIOSYNTHESIS OF LONG CHAIN FATTY ACIDS BY OLIGODENDROGLIA ISOLATED FROM BOVINE WHITE MATTER 1
Author(s) -
Fewster Mona E.,
Ihrig T.,
Mead J. F.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb06954.x
Subject(s) - palmitic acid , oleic acid , biochemistry , fatty acid , metabolism , linoleic acid , biosynthesis , biology , white matter , linolenic acid , ethanolamine , chemistry , enzyme , medicine , radiology , magnetic resonance imaging
— Radioactively labelled fatty acids were incubated with interfascicular oligodendroglial preparations isolated from 9 month fetal and adult bovine CNS white matter to study their metabolism by these cells. Of the various acids studied, the uptake was greatest for palmitic acid and decreased with decreasing chain length. Laurie acid was converted to the greatest extent to other fatty acids. The incorporation of oleic and linoleic acids in the oligodendroglia from both the fetal and adult brains was higher than that of linolenic acid. Fatty acids underwent chain elongation, desaturation and oxidation. Oleic acid was elongated to nervonic acid. Fatty acids were incorporated into both cerebrosides and phospholipids, with preferential incorporation into ethanolamine phosphoglyceride.