Premium
INHIBITION OF 5′‐NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES
Author(s) -
Tsuzuki Junji,
Newburgh R. W.
Publication year - 1975
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/j.1471-4159.1975.tb04424.x
Subject(s) - theophylline , theobromine , caffeine , xanthine , aminophylline , phosphodiesterase , 5' nucleotidase , chemistry , pharmacology , adenosine , endocrinology , medicine , biochemistry , enzyme , biology
—Rat brain 5′‐nucleotidase (EC 3.1.3.5) is inhibited by methylxanthines such as theophylline. Inhibition of the 5′‐nucleotidase by theophylline appears more efficient than the inhibition of cAMP phosphodiesterase by this drug. A similar inhibition is observed with caffeine, theobromine, 7′‐methyl‐xanthine and 1‐methylxanthine.